Endocrine Abstracts

Introduction: The super-super-obese category of patient (BMI >60) tend to respond poorly to conservative weight interventions. Bariatric surgery is therefore considered the best form of intervention. Only a few UK centres have expertise to manage patients with a BMI >100kg/m2 and careful counselling is essential as those standing to benefit the most from these procedures (through reduced risk of cardiovascular disease, diabetes and malignancy) also face the ...

Aim: In light of recent publications - could a lower cortisol cut off value of ~350 nmol/l be used to safely rule out adrenal insufficiency (AI) compared to current local guideline cutoff value of either a baseline or 9am cortisol of 420 nmol/l? If so could this potentially help reduce the number of Co-syntropin stimulation tests (CST) performed?Background: Current local guidelines recommend a cortisol cut value of 420 nmol/l to rule out adrenal insuffic...

Introduction: Water deprivation testing (WDT) is considered the gold standard test in differentiating between craniogenic diabetes insipidus (DI), nephrogenic DI and primary polydipsia. However, it requires day case admission for monitoring of sodium and osmolality. Copeptin, derived from pre-provasopressin, is secreted in an equimolar amount with arginine vasopressin and has a potential role in facilitating the diagnosis of DI and reducing the need for WDT. Copeptin was gradu...

Case history: 29 year old lady presented to A&E with UTI. She had a history of emotionally unstable personality disorder and was an elective inpatient in a psychiatric hospital at the time of her presentation. Blood tests done on admission showed that she was hypercalcaemic. She was treated for UTI and referred to endocrinology. Biochemistry tests were in keeping with familial hypocalciuric hypercalcaemia (FHH). It transpired that her father and sister also had hypercalcae...

Case history: A 74 years old gentleman with no medical illness presented with loss of consciousness in March 2018. CT head did not show acute cortical infarct but there was florid symmetrical calcification involving the basal ganglia, thalami, cerebellar lobes and subcortical white matter within the parietal-occipital lobes bilaterally. Fahr’s disease was suspected and an outpatient MRI was requested.Investigation and Results: 2 weeks later, a routi...

Thyroid uptake scan is a widely used thyroid investigation that provides valuable information regarding the structure and function of the gland and helps in differentiating some of the common thyroid pathologies. We present a multicentre audit of thyroid uptake scans done for non-malignant thyroid pathologies and try to analyse the usefulness of this investigation in different situations.MethodsThis audit includes thyroid uptake sc...

IntroductionWe present the case of a 50-year-old lady who was referred to the endocrine clinic with a clinical and biochemical picture suggestive of severe thyrotoxicosis. CT scan of thorax, abdomen and pelvis (CT TAP) was performed to rule out malignancy, which showed left lobe agenesis.Case50-year-old lady presented to the GP with hyperhidrosis and unintentional weight loss. She also reported symptoms of le...